WebNational Center for Biotechnology Information WebFigure 5. Uterine HIF2α places the implanting embryo in the bottom of the endometrial crypt through induction of LIF. ( A) The positioning of embryo attachment at the bottom of the endometrial crypt was impaired in Hif2a -uKO mice at 1000 hours on day 5. Scale bar, 100 μm; arrowhead, an embryo; s, stroma; le, luminal epithelium.
JCI - HIF2α signaling inhibits adherens junctional disruption in …
Web26 de nov. de 2024 · Enhanced HIF2α expression during human trophoblast differentiation into syncytiotrophoblast suppresses transcription of placental growth factor. Sci. Rep. 7 , … Web29 de set. de 2024 · Abstract. Hypoxia-inducible factor 2α (HIF2α) antagonists are effective against clear cell renal cell carcinomas (ccRCCs) that highly express HIF2α. To identify potential drug targets in HIF2α low/− ccRCC, we constructed an epigenetic-focused single-guide RNA library and performed an in vivo CRISPR-Cas9 knockout screen in BALB/c … can i check my rental history
USP37 promotes deubiquitination of HIF2α in kidney cancer
Web27 de mai. de 2024 · In kidney cancer, HIF2α is well established to be an oncoprotein that is sufficient and necessary to promote xenograft tumor growth (7, 8). HIF2α depletion decreased xenograft tumor growth in models using pVHL-deficient kidney cancer cell lines, and HIF2α overexpression can override the tumor suppressor effect of pVHL (7–9). Web13 de abr. de 2024 · Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders. PNAS, 107(25): 11459-11464. 16. Deng L, Zhang D, Richards E, Tang X, Long F, Fang J, Wang Y. (2009) Constructing an initial map of transmission distortion based on high density HapMap SNPs across the human … Web8 de mar. de 2016 · Repression of glucagon signaling by HIF2α ameliorated hyperglycemia in streptozotocin-induced diabetes and acute insulin-resistant animal models. This study … fit note required for ssp