Efficient synthesis of scutellarein
WebOct 19, 2011 · Scutellarein is a component of Scutellaria, recently known as a potent cytotoxic agent on human leukaemia cells. The aim of this study was the synthesis of … WebA practical and economical five-step synthesis of the flavone scutellarein has been achieved in 60% overall yield using the available and cheap 2,6-dimethoxy-1,4 …
Efficient synthesis of scutellarein
Did you know?
WebAbstract: In this paper, a new and efficient synthesis of 6-O-methylscutellarein (3), the major metabolite of the natural medicine scutellarin, is reported. Two hydroxyl groups at ... then 6-O-methyl-scutellarein (3) was produced in high yield after methylation of the hydroxyl group at C-6 and subsequent deprotection of the two methyl ether groups. WebMar 1, 2024 · An experimentally simple and efficient synthesis of 2-alkynyl-5-methoxy-1,4-benzoquinones is described. This involves the 1,2-addition of lithium acetylides to 4,5-dimethoxy-1,2-benzoquinone to...
WebFeb 25, 2016 · In summary, we have developed an efficient chemical synthesis of scutellarein (2) in high yield in only four steps. This strategy relies on acetylation, … WebFeb 1, 2024 · Synthesis of Scutellarein Derivatives with a Long Aliphatic Chain and Their Biological Evaluation against Human Cancer Cells Scutellarin is the major active flavonoid extracted from the traditional Chinese herbal medicine Erigeron breviscapus (Vant.) Hand-Mazz., which is widely used in China.
WebOct 19, 2011 · The aim of this study was the synthesis of scutellarein and its methylated derivative. The new features are the innovating method to afford flavones from … WebScutellarein is a component of Scutellaria, recently known as a potent cytotoxic agent on human leukaemia cells. The aim of this study was the synthesis of scutellarein and its methylated derivative. The new features are the innovating method to afford flavones …
WebOct 1, 2014 · In this paper, an efficient synthetic method for the construction of 5,6,7-trihydroxy-2-[4-[2-(4-morpholinyl)ethoxy]phenyl]-4H-1-benzopyran-4-one (5) is reported. …
WebScutellarin (1) is readily converted in vivo, therefore, synthetic methods for the construction of its metabolites will be very important in the near future. In this work, an efficient and … gumtree cars for sale brisbaneWebOct 23, 2012 · Scutellarin (40,5,6-trihydroxyflavone-7-glucuronide), primarily absorbed in the form of its hydrolyzed metabolite scutellarein (5,6,7,4′-tetrahydroxyflavone), has been validated to accelerate... bowling terms spareWebThis kind of scutellarein derivative (3) could be an efficient agent for ischemic cerebrovascular disease treatment. Open in a separate window. Scheme 1. The route of the synthesis of scutellarein derivate (3). (a) H 2 SO 4, EtOH, 120 °C, 48 h, 17.3%; (b) H … gumtree cars for sale chesterfieldWebSep 6, 2012 · In summary, an efficient route for the synthesis of scutellarein by hydrolyzing scutellarin was reported. Essential to the synthesis was the use of H 2 SO 4 in 90% ethanol under a N 2 … gumtree cars for sale by ownerWebpractical method for the synthesis of scutellarein under mild reaction conditions is still in demand. Results and discussion Our practical and economical five-step synthesis of scutellarein 1 is shown in Scheme 2. It was achieved in approximately 60% overall yield using the cheap 2,6-dimethoxy-1,4-benzoquinone as the starting material. gumtree cars for sale east lothianWebDec 1, 2013 · Scutellarin (1) is readily converted in vivo, therefore, synthetic methods for the construction of its metabolites will be very important in the near future. In this work, an efficient and first... gumtree cars for sale in didcotWebJul 26, 2016 · The phenolic hydroxyl groups of scutellarein provide important ‘synthetic handles’ for the structural modification of scutellarein and facilitate the design and synthesis of novel prodrugs with the potential for improved bioactivity and … bowling terms lingo