WebFeb 11, 2024 · Activation of Axl receptor tyrosine kinase has a key role in the growth and metastasis of several cancers [ 1 ]. In lung adenocarcinomas, the protein expression of … WebOct 3, 2013 · We report here that Axl, a member of the Tyro3, Axl, Mer receptor tyrosine kinase family, 2-4 represents an independent prognostic marker and therapeutic target in AML. AML cells induce expression and secretion of the Axl ligand growth arrest–specific gene 6 (Gas6) by bone marrow–derived stromal cells (BMDSCs).
558 - Gene ResultAXL AXL receptor tyrosine kinase [ (human)]
WebDec 7, 2016 · The receptor tyrosine kinase family consisting of Tyro3, Axl, and Mer (TAM) is one of the most recently identified receptor tyrosine kinase families. TAM receptors are up-regulated postnatally and maintained at high levels in adults. WebJan 18, 2024 · AXL is a member of the TAM family of receptor tyrosine kinases (RTKs) that also includes TYRO3 and MER. This was the last family of RTKs to be identified and … skillings service station buxton maine
Frontiers The Development of AXL Inhibitors in Lung Cancer: …
WebNov 4, 2024 · AXL is a member of the TAM family with the high-affinity ligand growth arrest-specific protein 6 (GAS6). The Gas6/AXL signalling pathway is associated with tumour … The Axl gene is evolutionarily conserved between vertebrate species. This gene has two different alternatively spliced transcript variants. The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique … See more Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene. The gene was initially designated as UFO, in allusion to the unidentified function of this protein. However, in the … See more The AXL receptor transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6 (GAS6). It is involved in the stimulation of cell proliferation and survival. Proteolytic … See more Cancer Several drugs classified as "AXL inhibitors" have entered clinical trials; however, many target multiple kinase receptors in addition to AXL. The most advanced AXL selective inhibitor is bemcentinib (BGB324 … See more Axl was first isolated in 1988 and identified as an oncogene in a screen for transforming genes in patients with a chronic myelogenous leukemia See more Studies have shown that AXL knockdown leads to downregulation of transcription factors required for EMT, including Slug, Twist, and Zeb1, and to increased expression of E … See more AXL receptor tyrosine kinase has been shown to interact with TENC1. See more • Neubauer A, Burchert A, Maiwald C, Gruss HJ, Serke S, Huhn D, Wittig B, Liu E (Mar 1997). "Recent progress on the role of Axl, a receptor tyrosine kinase, in malignant transformation of myeloid leukemias". Leukemia & Lymphoma. 25 (1–2): 91–6. See more skillings law office new ulm mn